Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund‐Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status
نویسندگان
چکیده
منابع مشابه
Update of Food-Cobalamin Malabsorption and Oral Cobalamin Therapy
Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age), but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspectives. In the general population, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorp...
متن کاملSelective Intestinal Cobalamin Malabsorption with Proteinuria (Imerslund‐Gräsbeck Syndrome) in Juvenile Beagles
BACKGROUND Selective intestinal cobalamin malabsorption with mild proteinuria (Imerslund-Gräsbeck syndrome; I-GS), is an autosomal recessive disorder of dogs caused by mutations in AMN or CUBN that disrupt cubam function and which can present as a medical emergency. OBJECTIVES To describe the clinical, metabolic, and genetic bases of I-GS in Beagles. ANIMALS Four cobalamin-deficient and 43 ...
متن کاملDegenerative Liver Disease in Young Beagles with Hereditary Cobalamin Malabsorption Because of a Mutation in the Cubilin Gene
Cobalamin is an essential cofactor for enzyme systems, and adequate amounts are required for nucleic acid synthesis and hematopoiesis. The 2 most important reactions involving cobalamin are the conversion of methylmalonyl-coenzyme A to succinylcoenzyme A and the remethylation of homocysteine. Cobalamin deficiency leads to decreased activity of these enzyme systems, resulting in increased concen...
متن کاملOral Cobalamin Supplementation in Dogs with Chronic Enteropathies and Hypocobalaminemia
BACKGROUND Cobalamin deficiency is commonly associated with chronic enteropathies (CE) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral and parenteral cobalamin administration of cobalamin. OBJECTIVES To retrospectively evaluate whether oral cobalamin supplementation can restore normocobalaminemia in ...
متن کاملEffective treatment of cobalamin deficiency with oral cobalamin.
Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days. Therapeutic effectiveness was evaluated by measuring hemat...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2018
ISSN: 0891-6640,1939-1676
DOI: 10.1111/jvim.15380